Types of injections
Injections of botulinum toxin type А:
Pharmaceutical form: Ampoule containing 100 units (formulation 900 kDa) of a dry neurotoxin complex (approximately 4.9 ng protein), 0.5 mg of human albumin, 0.9 mg of sodium chloride (pH equal to 7.0)
Pharmaceutical form: Ampoule containing 300 U (formulation 500-900 kDa) of dry neurotoxin (5 units correspond to 12.5 ng of protein), 2.5 mg of lactulose
Preparation of Botox Solution for Injection:
The manufacturer recommends the dilution of dry content in a sterile 3.0-0.9% solution of sodium chloride to obtain 4.0 U / 0.1 ml, although other dilution ratios are acceptable in practice, depending on the calculation of a specialist who always seeks to simplify the calculation of the doses introduced in Each region. The finished solution should be clear, colorless and free of suspended particles. The manufacturer recommends using the finished solution for 4 hours under storage conditions at a temperature of 2-8 °C.
Preparation of solution Dysport for injection:
300 U of dry content is diluted in sterile 2.5 ml 0.9% sodium chloride solution to obtain 4.0 U / 0.1 ml, although in practice other dilution ratios are acceptable, depending on the calculation of a specialist who always seeks to simplify the calculation of the doses administered In each area. The prepared solution should also be transparent.
Comparative characteristics of Botox and Dysport
Both preparations have significant differences both in the process of manufacturing technology, as well as in the calculation of dosing. It is also important to consider the difference in the composition of the preparations in terms of protein content. Botox in comparison with Dysport contains approximately 5.0 mg more protein per 100 units of the drug. The experience of clinical practice shows comparable effectiveness and safety of use of Botox and Dysport in the field of cosmetology. Due to certain differences in the characteristics of dose-dependent efficacy of each drug for specialists, it is recommended for a specialist to work with one medication in practice.
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