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Types of fillers



Injection fillers:
Fillers of collagen basis Zyderm I, Zyderm II, Cosmoderm, Cosmoplast
Fillers of hyaluronic acid basis (of animal origin) Hylaform, Hylaform Fineline
Fillers of hyaluronic acid (of bacterial origin) Restylane, Restylane Lipp, Perlane, (Q-Med, Sweden)
Teosyal (Teoxane, Switzerland)
Juvederm (Allergan, USA)
Elevess (Anika Ther.,USA)
Prevelle Silk, Puragen (Mentor Corp., USA)
Belotero (Merz, Germany)
Synthetic fillers:
Calcium hydroxyapatite (long-term)
Polyacrylamide (constant)
Polyalkilamide (constant)
Polydimethylsilocsane (constant)
Radiesse (Bioform Med., USA)
Aquamid (Contura Int., Danemark)
Bio-Alcamid (Polymekon, Italy)
Silikon-1000 (Alcon Lab., USA)
Combined fillers:
Polymethylmetacrylate + collagen (long-term)
Hyaluronic acid + dextranomers (long-term)
Artefill (Artes, USA)
crm-DEX (Biopolymer GmbH & Co., Germany)


Injection fillers are used for a variety of needs of cosmetology: fill wrinkles, can give volume to the lips and correct the fading or unattractive from the point of view of the client contour of the face.

The result of exposure is visible almost immediately, and the traces of the injections pass for a short time, which allows not to break the habitual way of life. Such procedures are therefore suitable for those who need to improve their appearance before any urgent events: a wedding, rest, a meeting. In this case, the effect will persist long enough.

In the modern sense, this technique is one of the least invasive methods of correction in the field of aesthetic or anti-age medicine.

When using fillers based on hyaluronic acid, it is necessary to take into account important parameters like the origin of HA, the concentration of HA in the syringe, the complementary substance of the HA polymers, the size and number of particles, the degree of binding (indicated in%), the content of HA in free form, What form the product is represented, that is, in the form of a monophasic (cohesive gel) or biphasic systems.

The elastic modulus indicated by the manufacturer (denoted as G) characterizes the hardness and stability of the gel to deformation when exposed to force.

Hyaluronic acid is a biogenic polysaccharide that is present in the extracellular matrix of all biological tissues and consists of a cyclic repetition of a unit of D-glucuronic acid and N-acetyl-D-glucosamine. Moreover, it is a structural component of tissues, having the ability to increase the mass 1000 times due to the attraction of water molecules. The half-life of hyaluronic acid is approximately 24 hours, after which it is split in the skin with hyaluronidase to the final products, such as carbon dioxide and water.

The most common fillers today are based on HA, which is synthesized in the process of biofermentation of microorganisms of Streptococcus equi strain. The manufacturer produces injectable fillers in filled syringes, usually the volume of the drug is 0.5 - 3.0 ml.

Monophasic systems (cohesive) are presented in the form of gels of visco-elastic consistency (for example, Juvederm, Teosyal).

Representatives of biphasic gels differ in the size of particles. Restylane Fine Lines, for example, contains 200,000 particles per 1 ml of product, whereas Perlane contains 10,000 particles, and Restylane Sub-Q has 1000 particles per ml. Thus, products with a higher concentration or larger particle sizes are designed to correct deep creases on the face (deep injections into the subcutaneous layers and dermis).

Hydroxyapatite of calcium

Radiesse (Bioform Med., USA) is a long-acting filler containing microspheres of calcium hydroxyapatite 25-45-nm, suspended in a carboxymethylcellulose carrier gel. Calcium hydroxyapatite in the Radiesse gel is identical in composition to the matrix of bone tissue, and having high biological compatibility, provides a long-term correction of deep wrinkles and folds on the face, and this filler is used to correct the zygomatic zone and the back of the nose, in addition to rhinoplasty. Later, after injection, microspheres undergo fibrous encapsulation and germination with collagen fibers, which, together with prolonged decomposition of calcium hydroxyapatite, provides a long-term filler effect (up to 1 year and more). It is recommended to avoid surface injections with this filler to avoid complications. The Radiesse filler is available in syringes with a volume of 0.3-0.8-1.5 ml for injection with a needle size of 27-28 and has a high viscosity, and compared with the HA after injection, palpation is more hard. The product is intended for deep injections (dermo-subdermal plane and subcutaneous fat layer).