RU | UZ | EN





Fillers (injection technologies)



In aesthetic medicine, one of the most effective methods of contour plasty of facial wrinkles in different areas of the face is the local filling of the area of the lost volume with the help of fillers. The restoration of volume contributes in the aesthetic sense to the re-creation of the harmony of the contours of the face.

Today fillers (English "filler" - "filler") are mostly represented by injection gels and are one of the most widely used methods of aesthetic medicine.

Injection of fillers have a long history. After the appearance of the liposuction method in 1975, many reports of surgeons were made about the use of autogyro as a filler with impressive results. Several years later, Gross and Kirk developed an injectable filler based on bovine collagen (Zyderm) (manufactured by INAMED Aesthetics, Canada). Later, a number of analogues with a higher content of collagen appeared.


In order to reduce the level of hypersensitivity reactions and simplify the technique of the procedure (the inconvenience associated with a double skin test) injectable fillers based on human collagen synthesized by bioengineering (Cosmoderm) were introduced into practice. A truly revolutionary event in cosmetology was the discovery and development of a molecule of hyaluronic acid by Dr. Endre Alexander Balazs in 1989. Hyaluronic acid (HA) was significantly different as a filler with high biological compatibility, as well as almost complete absence of immunogenic properties. At the beginning of the new century, after the completion of preliminary research, injectable fillers based on HA gained widespread recognition (Restylane, manufacturer of Q-Med, Sweden).

Then came a lot of drugs from different manufacturers, which were approved for use in cosmetology (Perlane, Juvederm, Elevess, Prevelle Silk, etc.). Fillers that contain hyaluronic acid are injections that help smooth out wrinkles, create attractive face contours with the effect of rejuvenation.

The hyaluronic acid molecule contains hydroxyl, carboxyl and sulfate groups with a negative charge, water molecules and ions, in particular Na +, are easily attached, and therefore determines the hydrophilic properties of the tissue. Being an important component of the intercellular substance, hyaluronic acid also participates in the formation of fibrous structures and the reparative processes of connective tissue. The advantages of fillers that are based on hyaluronic acid include the duration and reversibility of the effect (which is important for cases of technical error), as well as expanding properties.

There are different types of injection fillers produced by manufacturers in different countries, with new products appearing in recent years. In addition to restoring the volume of various zones in cosmetology practice, fillers are also used to create hypercorrection (lip augmentation, giving the volume of the zygomatic area, etc.).